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The hypotheses assumed. Only if the time horizon was set to 8 weeks, there would be an important increase on the incremental cost utility ratio. In fact, for a time horizon of 8 weeks the cost per QALY is 58,093. However, it should be clarified that the time horizon for economic evaluations of drugs is often extended beyond the duration of the clinical trial. This is so because clinical trials ar
Ey rely on the resource consumption pattern estimated through the expert panel, the incremental costeffectiveness ratios would be 29,400 and 85.Sensitivity analysisOne-way deterministic sensitivity analysis was performed on the time horizon, assuming 8 weeks and 24 weeks; on the utility values considered, evaluating the impact of using the ones obtained on the PEACE study (0.83 for HAM-A score 9
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I.e., it is both cheaper and more efficacious. To our knowledge, there are only three economic studies comparing pregabalin to venlafaxine XR [8,9,33]. NICE [8] performed an economic evaluation based on a network meta-analysis in which the probability of discontinuation due to serious adverse events and the probability of response in patients without those adverse events were estimated. Pregabali
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Sactivation of PDGFR, and PI3K/JNK/c-Jun (AP-1). Moreover, LTAinduced MMP-9 expression is positively associated with cell motility (migration) in the RBA-1 cell culture model.MethodsMaterialsDMEM/F-12 medium, FBS, and TRIzol were from Invitrogen (Carlsbad, CA, USA). Hybond C membrane and ECL western blotting detection system were from GE Healthcare Bio-sciences (Buckinghamshire, UK). MMP-9 antibo
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On of these signalingcascades and transcription factors has been reported to be involved in induction of MMP-9 in rat astrocytes [20,24,25]. Moreover, transactivation of receptor tyrosine kinases such as platelet-derived growth factor receptor (PDGFR) by several stimuli has also been implicated in mediating cellular functions of glial cells [29]. More recently, we have demonstrated that LTA induc
Rse events or lack of efficacy and that, according to the expert panel, they would switch to paroxetine, whose mean change from baseline was set at 50 , based on published data [24-27]. This was also assumed for those patients for whom the panel indicated a concomitant use of venlafaxine andSilva Miguel et al. Cost Effectiveness and Resource Allocation 2013, 11:8 http://www.resource-allocation.co
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